Chemoenzymatic Total Synthesis of Natural Products

Lessons from total synthesis of hybrid natural products.

There are a vast number of interesting and useful compounds that are readily found in nature. Mother Nature has acquired ingenious ways of generating molecular diversity in living cells responsible for regulation of various biochemical events. This has inspired research into the synthesis of biologically active compounds for use as antibiotics or in cancer therapy, for example. This account pro...

Total Synthesis of Bioactive Natural Products - A Personal Perspective

Total synthesis of complex molecular architectures has long been recognized as the most powerful form of training for synthetic organic chemists. This historical discipline has a rich and glorious tradition in both teaching and research, and is an indispensible component in any chemistry department and scientific institutions. Scientifically, in addition to the synthetic challenges associated w...

Structural revisions of natural products by total synthesis.

Total synthesis and development of bioactive natural products

The first total synthesis and development of a variety of bioactive natural products have been accomplished by using carbohydrates as a chiral source. In addition, practically useful intermediates have been created, analogs of natural products have been prepared, their structure-activity relationships studied, and the large-scale preparations of medicinally useful compounds established. The key...

Total synthesis of natural products using hypervalent iodine reagents

We present a review of natural product syntheses accomplished in our laboratory during the last 5 years. Each synthetic route features a phenol dearomatization promoted by an environmentally benign hypervalent iodine reagent. The dearomatizations demonstrate the "aromatic ring umpolung" concept, and involve stereoselective remodeling of the inert unsaturations of a phenol into a highly function...